Yes, according to several studies. Both short and longterm use of
oral steroids – for arthritis, autoimmune disorders, and other conditions – has been found to impede learning and memory, possibly by altering the brain’s hippocampus region. Corticosteroids can also cause mood changes and sleep problems, which in turn could hinder memory. A small study in 2007 found the effect is usually strongest right after starting treatment and tapers over time. It might be reversed if you stop taking the drug, lower the dose or take it later in the day, according to an analysis of 16 studies. For people on longterm corticosteroid therapy, there’s limited evidence that the neurolog ic drugs Lamotrigine (Lamictal and generic) or Memantine (Namenda and generic) can help counter memory decline.