Article – Can corticosteroids affect one’s memory?

Yes, according to several studies. Both short and long­term use of

oral steroids – for arthritis, autoimmune disorders, and other condi­tions – has been found to impede learning and memory, possibly by altering the brain’s hippocampus region. Corticosteroids can also cause mood changes and sleep problems, which in turn could hinder memory. A small study in 2007 found the effect is usually strongest right after starting treatment and tapers over time. It might be re­versed if you stop taking the drug, lower the dose or take it later in the day, according to an analysis of 16 studies. For people on long­term corticosteroid therapy, there’s limited evidence that the neurolog­ ic drugs Lamotrigine (Lamictal and generic) or Memantine (Namenda and generic) can help counter memory decline.